User blog comment:VampireFan1996/Favorite main mystery/@comment-5066566-20110829225437

I chose Mary Alice because that was truly the most shocking mystery. We're introduced to a woman who lives a perfect, yet normal, life with her seemingly perfect family and then we see that she has a horrible secret and then she kills herself. And then we get so emotionally involved with the journey to discovering her secret, and also there's the suspense with Paul covering up the secret and then we get introduced to the most epic conflict in TV history, Paul and Felicia! It was just such a great way to start a series, there were such a lot of great characters involved - Mary Alice, Paul, Felicia, Martha, Dr. Goldfine, Zach, Deirdre, Mike - the list goes on! And obviously when the secret was revealed, we weren't disappointed. It was a tragic story that I'm sure anyone could find themselves in. She made a mistake, she just reacted to save her family, and that's the saddest part!

However, don't get me wrong, I love the other mysteries. If I had to put them in an order, I'd say:
 * 1 - Mary Alice
 * 2 - Katherine
 * 3 - Betty
 * 4 - Paul
 * 5 - Angie
 * 6 - Dave
 * 7 - Orson