Chicago is a major city located in Illinois, and the hometown of Betty Applewhite and Katherine Mayfair. Fairview is repeatedly implied to be a suburb of Chicago, with local stations reporting Chicago news and more than one reference to characters flying in from Chicago's O'Hare airport. Katherine and Bob and Lee have mutual friends in Chicago. The city is also where Melanie Foster, Matthew Applewhite's girlfriend, was murdered. Betty believes that her mentally challenged elder son Caleb is responsible -- which is why she is hiding out on Wisteria Lane with Caleb locked in her basement -- but in reality, Matthew killed her when she wouldn't stop making fun of Caleb.

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