Karen's unnamed son was the son of Karen and her husband Gilbert McClusky. Karen told the Scavo boys he got sick and died when he was just 12 years old. Karen tells them that he was just like them, a 'real hellraiser', and that they would have liked him. Karen also expresses the pain of losing her child to Edie Britt during a flashback sequence in Look Into Their Eyes and You See What They Know.
Little Mr. McCluskey and his mother in their younger years.("You're Gonna Love Tomorrow")
Karen's son pictured here, ("Love is in the Air"), is not the same boy that appeared in ("Finishing the Hat").
When Susan Delfino decides to leave Wisteria Lane with her two children, and granddaughter, his ghost appeared alongside his mother, and they watched the family as they drove away from the lane and began their new lives together. ("Finishing the Hat")
Karen's son's ghost watches Susan leave Wisteria Lane. ("Finishing the Hat")