Samuel Page was born in . He attended Princeton University, where he earned a BA in ecology and evolutionary biology He captained the football and baseball teams at Whitefish Bay High School.
After completing his degree, Page decided to become an actor despite having no high school acting experience. "I came home and told my mom and dad I was moving to Hollywood to become an actor."ik909
While in Los Angeles, Page appeared on the television shows Men, Women & Dogs, Undressed, 7th Heaven, Popular, Hang Time, and Border Town. In New York City, he was cast in 2002 as "Trey Kenyon" on the daytime drama All My Children.
Page had a recurring role in American Dreams and guest starred in other series, such as CSI: Miami and Wicked Science. In 2005 he was cast as "Jesse Parker" on Fox's supernatural drama Point Pleasant. In 2006, he had a starring role on the CBS drama series Shark. He plays Joan Holloway's fiancé and then husband, Greg Harris, on Mad Men and in 2010 appeared in a multi-episode arc on ABC's Desperate Housewives as Sam, son of Rex Van de Kamp (Steven Culp) and stepson of Bree Hodge (Marcia Cross).
In 2008, Page appeared in Will.i.am's video Yes We Can in support of Barack Obama's presidential bid, along with numerous other celebrities.
In addition to his television credits, Page's film credits include The Brotherhood, Prison of the Dead, and Microscopic Boy.
In 2010, Page played a young College professor and also Serena's new love interest in Gossip Girl as "Colin Forrester".
Page appeared on the cover of the February 2011 issue of J. Crew's clothing catalogue and magazine.