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This portal shows the characters whose main portrayers have received a "Starring" billing in the series, even if such characters haven't appeared in many episodes, or if their portrayers have been shown in one or several episodes as supporting, recurring or guest castmembers. They are ordered by the number of episodes they were seen in and, in case they were in the same number of episodes, alphabetically. The series narrator, Mary Alice Young, is saved for last.

Key

 Alive
Portal:Main Characters
 Deceased
Portal:Main Characters

Main Characters

 Susan
Susan Delfino
 Bree
Bree Van de Kamp
 Carlos
Carlos Solis
 Tom
Tom Scavo
 Mike
Mike Delfino
 Edie
Edie Britt
 Julie
Julie Mayer
 Orson
Orson Hodge
 Karen
Karen McCluskey
 Andrew
Andrew Van de Kamp
 Paul
Paul Young
 Lee
Lee McDermott
 Renee
Renee Perry
 Bob
Bob Hunter
 Karl
Karl Mayer
 Zach
Zach Young
 Rex
Rex Van de Kamp
 Dave
Dave Williams
 John
John Rowland
 Angie
Angie Bolen
 Betty
Betty Applewhite
 Ben
Ben Faulkner
 Ana
Ana Solis
 Chuck
Chuck Vance
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